I really like Brother's. Have been here 3 or 4 times now. It is better when it is less busy, like on a weeknight, because the service is naturally quicker. They always have a variety of live music. With three different bars (front bar, wine bar, back bar where the large stage is), you can always escape to the more quiet one if you want to talk.
My bf always raves about the bar back who works here. Just watch him sometime, he actually is incredible. He is fast as hell and actually rotates the beers in the cooler and front-faces them. So you can see what beers are there and you know they are actually fresh. Such a basic concept but tell me the last time you saw someone at a bar rotating their stock.
The crowd is typically older than most bars, which is good, in my opinion. However, if you are 21 and just looking to get lit on shots, you might want to pick somewhere else.