As far as convention centers go, this place is huge and not too poorly laid out.
You'll probably find it difficult to find parking. Here's a tip: drive inside by the Southhall and stay on the inner Lane. There is a parking section there for people who are working the booths. But if you go up to the parking guy and hand him a 10 in addition to the $10 it cost to park, it is likely that a spot will "open up".
Otherwise you will find yourself in the parking structure across the street, so if you are a lady I suggest flat :-) The area is divided into four halls. It's actually relatively easy to navigate. The only downside is that food tends to be in the back and it closes quite early. If you're hungry, do not wait until 4 PM to go forage.
Restrooms are pretty clean and layout is decent. Lighting is pretty bad, so you might feel like you've been in a dungeon for several hours.
Overall as convention centers go, this is one of the better ones. There are also several local hotels that are off strip here that are pretty cheap and allow you to walk over.