This is probably my favorite venue in Pittsburgh. It's a great size, with the bar area separated towards the back. I've taken photos for a magazine here many times. The bouncers and security are extremely nice, and it's fairly easy to jump into the photo pit. Sometimes they will even let photographers hang out on the side of the stage to shoot. Experiences like these make even my regular visits to Mr. Small's better.
If you're coming from the city (students!), it's probably easiest to just split a cab with friends or bring someone with a car. Taking busses here can be an arduous process. Overall one of the best vibes from a live music venue in PGH.