As far as Goodwill locations go, this store is pretty good. If you are looking for clothing, particularly denim jeans and t-shirts, this is one of the most well-stocked in Vegas. It's not great on the housewares, dresses or furniture so if you are looking for those things I would recommend one of the other Goodwill stores in town.
The aisles are super tiny so don't get a cart unless absolutely necessary. The clothing racks are overstuffed with merchandise, making it difficult to browse or move the clothes hangers. This store in particular is very, very popular with the elderly: they'll be clogging the aisles shopping next to you and they like to donate all of their free casino crap t-shirts, drinking glasses and other random Station Casinos logo'ed "trinkets of treasure" here (guess it's better than giving them as X-mas gifts to the grandkids)!
Check the sign when you come in because this location offers lots of sales and specials. The quality of stuff is what you'd expect at Goodwill (if you want items in nicer condition, check out Savers instead) and the prices are low. I've scored awesome vintage t-shirts in decent condition for 50 cents. Can't beat that, fellow hipsters!