I had my wedding rehearsal dinner at Grano this past January (2012) and was really impressed with everything. It's always tricky when making reservations for a large group (there were 16 of us). I worked with the manager Roberto on a prix fixe menu so we didn't have to worry about ordering and everything could come out at the same time (family style). He asked for a picture of us and printed out the custom menu and had it set out at each place setting - a very nice touch.
We had the back room which was nice and private. We also had a toddler and a baby with us so they could walk around the space and not disturb any other patrons. It was also nice an intimate for when we made speeches.
The food was delicious and the timing of when everything came out was perfect. They even threw in a few extras for free - great value. The service was also impeccable. I highly recommend Grano for a large group.