Most Wanted is one of the galleries over in the Penn Ave arts corridor in Garfield, situated right about in the middle of the stretch. They regularly participate in the Unblurred First Friday gallery crawls that happen on the first Friday of each month, but are also able to be rented out for private events.
The gallery itself is quite a nice space: shiny hardwood floors, the ability to open up the front in nice weather, and an exposed brick wall. They also have a little stage area for live music. The quality of the art they bring in is consistenly quite good as well, and especially on First Friday, you have a good chance of meeting and getting to chat with the artist(s).
On First Fridays, they sometimes offer wine tasting from Wilhelm Winery (or have other free booze) and usually have a good sampling of snack-upons.