There are already great, extensive reviews written about this store. I'll just echo them and say that pretty much anything you go looking for, you'll find at this store. This one is a lot bigger than the one on 3rd Street and McDowell. Anytime I need something a bit strange, I go to this Safeway. I would shop there all the time, except I don't. :) I like to mix it up.
I would be happier if they had more in the organics/natural food department. There are a lot of things they don't carry (i.e. Amy's soups, Quorn products, etc) and for that, they lose one star.
One more thing: the employees are extremely friendly and helpful. I'm grew up in the Midwest, and when I started shopping at Safeway, I was really unnerved by how much they talk to you ("How are you doing today? Do you need help finding anything?"). Now I'm realizing that perhaps I was the weird, quiet one. I can't help it. I'm Scandinavian.