This is by far my favorite show on the strip. I've seen almost all of the cirque shows but I make sure to see this one 4-5 times/year. It is spectacular! The venue is circular so, no matter where you sit, you'll always have a great view of the entire show. I recommend getting seats in the middle rows (from bottom to top) for the greatest experience.
Like most Cirque shows, all of the music is played live, along with the performance. The pool and the height of the venue are used to their fullest extent - even an amazing dive from so far up, you can't even see where the diver jumps from.
If you're wondering what show to see, this is the one you have to check out. Besides, it's in the Wynn/Encore which is a great hotel/casino. Wynn really pays attention to detail when building his monstrosities and you won't be disappointed.
Can't wait to see it again!