I'm downtown often so going to Myriade for my caffeine fix is always the highlight of my day when I have to go in this busier core of the city. Myriade is a nice change from the heavy selection of generic coffee chains found in this area and it's the only independent coffee shop this side of town (but I may be wrong, I only go here!).
They have a nice coffee/tea menu, sell coffee beans from independent distributors, and a delicious selection of baked goods (vegan muffins anyone?) They even sell Saint Donuts' donuts who make the best apple fritter donuts I've ever sank my teeth into. Nom.
It's never busy enough where you have to wait very long for your coffee but there is never room to sit down as it always packed which, in my opinion, is not a bad thing.
The patrons tend to be a mixture of people from professionals to students. The staff is always cordial and efficient. Be prepared to be a regurlar at this unpretentious coffee shop :)