THE best consignment shop in all of Pittsburgh hands down (and I believe I've been to all if not most)
The location is a little out of the way for city dwellers but it is definitely worth the $3 dollars in gas. A majority of their clothing is well priced and they have an excellent selection. Their jewelry is out of my price range with some pieces costing just $10 while others can go as high as $100+.
If you're one to care about brands than this is definitely a place you want to visit, they carry almost only brand names like BCBG, Cole Haan, etc.
Also they have a bunch of promotions, coupons, and perks.