I've been a few times- biggest down side for those who are gluten free; no beer options. I didn't see a wine list while I was there either. Another down side is the lack of gluten free dishes --going to Penn Brewery as a gluten free person is a typical "I guess I'm getting a salad" experience. However, I really enjoyed their grilled chicken salad- the chicken was cooked perfectly. It was a very nice portion size as well. I've also gotten the steak cob salad --pretty good too. Nothing out of this world, but I know my non-gluten free friends love the food and beer options.
They have a patio out back that looks like a fun time in warm weather to go with friends- I would go back just for the atmosphere.