As another Yelper mentioned, Spirits Bar & Grill is home to Jo-Anna Downey's "Open Mic" Stand Up Comedy show every Wednesday night at 9 pm.
She just had her 15 year Anniversary Show, and WOW what a show!
It is not really an "Open Mic", as comics are booked in advance, but you never know who will be on...
Here is an excerpt from her website:
"Spirits is known as the home away from home for out-of-town comics who drop in from all over the globe and one never knows who will visit our stage.
There have been many memorable shows over the years:
* Mitch Hedberg came by to hang out and Jo-Anna performed his material for him.
* Harland Williams and his cousin Kevin Hearn (of Barenaked Ladies fame) rocked the mic during the only show that Jo-Anna has ever co-hosted - with Kevin's dad Pat!
* Jo-Anna's 40th birthday show was notoriously crashed by Robin Williams and Lewis Black.
* Patton Oswalt graced the Spirits stage before becoming one of the "King of Queens" gang and a Comedy Central hero.
* Jo-Anna stood in fear while a random clown rushed the stage (that everyone in the room thought was a planned stunt) and she's also been upstaged by her own niece.
* Michael Moriarty (from Law and Order) is credited with the most surreal experience in the history of Spirits Open Mic Night.
Mike Wilmot, Sandra Shamas, Sean Cullen, Kenny Robinson, Nikki Payne, Debra DiGiovanni - the list of amazing performers go on and on.