This is a one-of-a-kind supermarket. Bi-rite is an unusual chain in that it gives a great deal of autonomy to the individual stores; it is more like a collaborative of independent supermarkets than it is a supermarket chain per-se.
The prices here are slightly-above-average, but only slightly. The products stocked are skewed somewhat towards the Gourmet end of things, Skewed a little bit towards the Italian end too. The produce is above-average--certainly blows away competitors like Tops and Giant Eagle, but perhaps lags behind the produce at nearby Nature's bin. There is an outstanding selection of alcohol too, including some esoteric beers that I have never seen anywhere else.
Between this place and Nature's Bin, I think that Cleveland Heights near Cedar/Lee has great supermarket shopping options. I only feel sorry for the people who live in other parts of Cleveland where good options aren't really available.