Secluded from the rest of Mandalay Bay is THE Hotel. A group of us were fortunate enough to book a suite before they were sold out due to the Kahn-Garcia fight.
Although we were not able to upgrade to a view of the strip our suite was SWEET. THE bathroom consisted of a stand up shower, a largeseperate bath tub, and a separate, adjacent toilet with it's own door. Also, there was a half bath located next to the entrance. THE separate living room, was spacious while the seating was very comfortable. I'll admit, the TV's need to be updated - low def :/ The couch was quite comfy the night I was stuck sleeping on it.
I think the best element to THE Hotel is that it's quiet and separate from the main casino yet only a few steps away from the Mandalay Bay Casino amenities. Definitely not your cheapest option on the strip; but in my experience, it was well worth the price.