Best hotel in Vegas. Nicest rooms, great restaurants (Okada rocks for sushi), beautiful lobby, great pool, bright/roomy intimate casino, low-smoke. Google visitwynn to look for deals (Wynn mails out promos that link to the visitwynn site) which are usually around $199/nt and checkout code AMEX always gets you 10% off regular rates whether or not you pay with an amex.
Don't expect casino room comps unless you are a big time gambler (i.e. gamble thousands of $ during your stay and/or have like 8+ hours a day of play). I basically get laughed at when I ask for comps though one time I was there with a group of people and we all played on the same card and got some comps.