I've been here at for a Blue Jays game or 2 over the years and enjoyed the experience, even though I don't like domed stadiums or artificial turf. However, the sliding roof is kind of cool.
Skydome is convenient from Downtown and right next to the CN Tower. You can also stay overnight here via the Hotel that shares the outfield with the Stadium. And during the baseball off season, there's always the Argonauts of the CFL to enjoy.