The Wynn is probably the best casino on the strip for anyone who has a little bit of money. I've never stayed here since I'm a local, but I've had friends who have booked gorgeous rooms.
I come here more for the food; the restaurants are top notch. Bartolotta is rated top 5 in Las Vegas, Strata is good for late night eats, Okada is delicious.
I'm not a big fan of the clubs here because the staff are kind of pretentious douchebags at both places, but the hotel, gaming, food are all top notch.