Even though I have a Lowe's close to the house, which I do use only in a pinch, Home Depot always has the best prices on major purchases and a better selection and pricing overall.
For example when we bought our new front loading washer and dryer this past summer Home Depot had the best price on a Maytag set with only $99 for the pedestals and free set up and delivery which saved us over $600 off of regular price. I also like the tool brand, Husky better as well. Just scored a Black Friday patio heater for $99 that had better reviews than the one Lowe's sold.
Overall the stores are clean and the sales staff is helpful.
For selection and pricing I would rather go to Home Depot than Lowe's anyday.