While I can't say I've ever actually purchased anything for myself, I keep coming back to My Sister's Closet. It's probably more the thrill of the hunt for that perfect (shirt/pants/jacket/etc) that keeps me interested. Maybe its just me, but they usually don't have much in my size. They do have plenty of Med - Large sizes and 35 - 40 waist pants.
FYI MSC - I wear a 38s jacket, size S collared shirts, a 30ish waist with 29inch inseam, and size 7 1/2 - 8 shoe; just in case you were wondering. ;)
My wife seems to have some luck though. She's found a few designer shirts, a couple pairs of 7 jeans, and even some cool Coach purses. I think this is definitely a better place for the female shopper.
Best of luck to all you shoppers; and who knows, maybe you'll bump into me in there not buying something. :(