First Friday is one of my favorite Vegas activities. I've been attending on and off for about two years now and can say it has evolved a bit over that time. I've heard it was shut down for a bit as there was some issues over who ran things but glad to see it's back.
For those who haven't been there are two locations; one near Fremont St and another near Charleston & Main, I prefer the latter. Once can usually find parking near 4th and Colorado. Walk west to the Colorado and Casino Center intersection then go north and enjoy the festivities.
You could say there is something for everyone, everyone who appreciates good eats, interesting arts, and libations that is. The food trucks and art vendors rotate out, there are some regulars. I'm too lazy to go into detail on everything there, besides it would ruin the surprise. You should go and check it out yourself!
Safety notes: lot's of people there, while Metro is always out in force and I've never had a problem I'm sure there are pickpockets and other undesirables looking for an easy score, don't enjoy too many good beers and watch out!