I've been here quite a few times for various types of concerts. Park nearby in one of the garages for $10 or if you get lucky, snag a street spot. Make sure to double check the times on the signs! None of them are the same. If you have a band here you want to see, don't hesitate, because many of them sell out quickly. It isn't a very large venue, but that just makes for a more intimate concert experience. Concerts I've seen here:
Chevelle
Excision
Madeon
The sound has always been well done. I wear eareplugs with filters to the concerts because I'm usually in a bit of pain after a long night. The speakers certainly won't disappoint. Excision had absurdly crazy bass and there didn't seem to be any problem meeting those demands. I think that the bathroom attendants are unnecessary but mostly because it's just awkward that I didn't tip you for handing me a paper towel... There is a medium sized area right in front of the stage for standing, and various areas around the main floor for staying out of the big crowd. The balcony can be nice if you want a good view.
I've never bought the food, so I can't comment on that.
Drinks are expensive, as in $10 for a pounder/tallboy. It's probably for the best; it keeps the crowd from getting too drunk. I'll be coming back here for many reasons, but mostly because the House of Blues is one of the few concert venues in Northeast Ohio that actually brings bigger name bands in.