Having been to Vegas numerous times, I've stayed and experienced a lot of different hotels. The Delano was definitely my favorite. The rooms are renovated, modern, and clean and the bed was so comfortable.
The hotel is at the end of the strip and there is no casino in the actual building, which for me was a plus since it was a bit quieter and when you walked in there weren't hundreds of people swarming. Depending on what you are looking for out of a Vegas experience, this may or may not be for you. But for me, being above the age of 22, this was great. The walk to the adjoining Mandalay Bay however was really short so you had access to the casino, pools, dining, you name it.
I would definitely stay here again!