My favorite coffee shop downtown. Features coffee from all over the world, nutritious smoothies, and tasty pastries and pre made deli sandwiches. Simpatico is the first place in Pittsburgh to feature a kale beverage. The barista is always on point and there is some old Life magazines to flip thru if you didn't bring anything to read.
Also, this is a great spot to ask for directions downtown since bike messengers usually hang in the lobby. ;)