The advantage to a chain - any chain, not just a Lowe's - is that you get what you get when you go in. And there is little to no difference here. I like Lowe's better than Home Depot these days because their service is better, they really strive to help you out. It used to be that Home Depot would be friendlier when you went in. Now neither really does so - but at least if you ask for help at Lowe's, they will help you.
At this location, it's a new store, and they are generally well-stocked on about everything you could need (and then some) around the house. Nice.