I suspect I'll get into trouble with the locals but I can't help myself. I have to gush a little bit about Ascari.
Went with a large group and they accommodated us without any difficulty. That said, the restaurant was FULL. You definitely want to get a reservation if you're bringing a posse.
This was an all around excellent dining experience - from the service to the wine to appis to the mains to the...well, ok, the coffee for dessert was probably my least favorite part of the meal but everything else was absolute perfection.