I came here for a show while visiting Toronto for the first time and I really enjoyed it. The bar staff was really friendly and the drinks were much more reasonably priced than I expected.
Like everyone else has said in their reviews, the actual stage space is pretty small. It's set up with two tables to a row, with three chairs at each and a narrow aisle in between. If you want to get a front row seat, definitely show up early. The show I saw was pretty packed and people were lining up 30 mins in advance, but since this was my first time here I'm not sure if that's the norm.
The bar area is bigger and there are plenty of tables around the room. It's kind of split into two sections, with the bar somewhat in the middle. They had a TV (maybe two, I don't exactly remember) on one side with sports on.
Overall I really enjoyed Comedy Bar and would definitely recommend stopping in for some good standup. One of the locals I chatted with said it's a pretty well known venue for comedy, so I'm sure you'll get a good show!